citrate
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Name: citrate
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Description: A tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid. (CHEBI:133748)
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 17474139 | Age 36.6 ± 5.5, Gender ⚥ | 220.3 (mmol/mol ) | H-NMR | urine |
| 17474139 | Age 54.5 ± 7.6, Gender ⚥ | 235.0 (mmol/mol ) | H-NMR | urine |
| 24457528 | Age 100.7 ± 2.1, Gender ⚥ | 1.01 (mean of regulated metabolite) | H-NMR | serum |
| 24457528 | Age 70 ± 6, Gender ⚥ | 0.82 (mean of regulated metabolite) | H-NMR | serum |
| 24457528 | Age 100.7 ± 2.1, Gender ♀ | 1.0 (mean of regulated metabolite) | H-NMR | serum |
| 24457528 | Age 70 ± 6, Gender ♀ | 0.81 (mean of regulated metabolite) | H-NMR | serum |
| 24457528 | Age 100.7 ± 2.1, Gender ♂ | 1.01 (mean of regulated metabolite) | H-NMR | serum |
| 24457528 | Age 70 ± 6, Gender ♂ | 0.83 (mean of regulated metabolite) | H-NMR | serum |
| 27374292 | Age [25–35] (median=32), Gender ♂ (Japanese) | 0.84335 (average level of metabolite) | UHPLC-MS/MS Negative mode | serum |
| 27374292 | Age [55–64] (median=60), Gender ♂ (Japanese) | 1.119249 (average level of metabolite) | UHPLC-MS/MS Negative mode | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 23838602 | Age [17–85], Gender ⚥ | 0.019 (β) | UHPLC/MS/MS | serum and plasma |
| 23838602 | Age [17–85], Gender ⚥ | 3.03 (β) | UHPLC/MS/MS | serum and plasma |
| 23838602 | Age [17–85], Gender ⚥ | 2.84 (β) | UHPLC/MS/MS | serum and plasma |
| 23838602 | Age [17–85], Gender ⚥ | 1.88 (β) | UHPLC/MS/MS | serum and plasma |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 29090929 | Age 42 ± 12, Gender ♀ | -0.099 (log2 ratio) | NMR | blood |
| 29090929 | Age 41 ± 12, Gender ♂ | -0.092 (log2 ratio) | NMR | blood |
Summary
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Synonym:2-hydroxytricarballylate
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Chemical Formula:C6H5O7-3
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Systematic name:2-hydroxy-1,2,3-propanetricarboxylic acid, ion(3−); 2-hydroxy-1,2,3-propanetricarboxylate(3−);2-hydroxypropane-1,2,3-tricarboxylate
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SMILES:C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
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InChI:InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3
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InChI Key:KRKNYBCHXYNGOX-UHFFFAOYSA-K
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CAS number:126-44-3
Related resources
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Literature sources:
- Menni C et al., Metabolomic markers reveal novel pathways of ageing and early development in human populations., International journal of epidemiology, 1111-9, 2013
- Psihogios NG et al., Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics., NMR in biomedicine, 195-207, 2008
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
- Montoliu I et al., Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity., Aging, 9-25, 2014
- Vignoli A et al., Age and Sex Effects on Plasma Metabolite Association Networks in Healthy Subjects., Journal of proteome research, 97-107, 2018
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External links:
Pathway info P = product of S = substrate of
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Tissue
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Metabolite source:Homo sapiens, endogenous metabolite
Age-variations
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 0.019
(y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 3.03
(y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 2.84
(y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 1.88
(y = βx + α)
p-value < 0.05