Pathways

• Metabolite associated pathways
• Metabolite in pathways

Metabolite	Pathways
1,7-dimethyluric acid KEGG C16356	Caffeine metabolism Metabolic pathways
1-methylnicotinamide KEGG C02918	Nicotinate and nicotinamide metabolism Metabolic pathways Bile secretion
1-methylxanthine KEGG C16358	Caffeine metabolism Metabolic pathways
11,12-dihydroxy-eicosatrienoic acid KEGG C14774	Arachidonic acid metabolism Metabolic pathways Serotonergic synapse
4-acetamidobutanoate KEGG C02946	Arginine and proline metabolism Metabolic pathways
4-hydroxybenzoic acid KEGG C00156	Ubiquinone and other terpenoid-quinone biosynthesis Folate biosynthesis Metabolic pathways
4-hydroxyphenylacetate KEGG C00642	Tyrosine metabolism Phenylalanine metabolism Metabolic pathways
4-methyl-2-oxopentanoate KEGG C00233	Valine, leucine and isoleucine degradation Valine, leucine and isoleucine biosynthesis Metabolic pathways 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids
5-methylthioadenosine (MTA) KEGG C00170	Cysteine and methionine metabolism Metabolic pathways
8-iso prostaglandin F2α KEGG C13809	Arachidonic acid metabolism
9-oxo-octadecadienoic acid KEGG C14766	Linoleic acid metablism
D-glucose KEGG C00031	Glycolysis/Gluconeogenesis Pentose phosphate pathway Galactose metabolism Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism Neomycin, kanamycin and gentamicin biosynthesis Metabolic pathways ABC transporters HIF-1 signaling pathway FoxO signaling pathway AMPK signaling pathway Taste transduction Insulin signaling pathway Insulin secretion Prolactin signaling pathway Glucagon signaling pathway Carbohydrate digestion and absorption Bile secretion Mineral absorption
D-glucuronate KEGG C00191	Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Amino sugar and nucleotide sugar metabolism Inositol phosphate metabolism Metabolic pathways
D-mannitol KEGG C00392	Fructose and mannose metabolism Metabolic pathways ABC transporters
D-mannose KEGG C00159	Fructose and mannose metabolism Galactose metabolism Amino sugar and nucleotide sugar metabolism Metabolic pathways ABC transporters Lysosome C-type lectin receptor signaling pathway
D-ribose KEGG C00121	Pentose phosphate pathway Metabolic pathways ABC transporters
D-sorbitol KEGG C00794	Fructose and mannose metabolism Galactose metabolism Metabolic pathways ABC transporters
D-xylose KEGG C00181	Pentose and glucuronate interconversions Amino sugar and nucleotide sugar metabolism Metabolic pathways ABC transporters
Dihydroxymandelic acid (DHMA) KEGG C05580	Metabolic pathways
L-alpha-glycerophosphoryl choline KEGG C00670	Glycerophospholipid metabolism Ether lipid metabolism Choline metabolism in cancer
L-carnitine KEGG C00318	Thermogenesis Bile secretion
L-citrulline KEGG C00327	Arginine biosynthesis Metabolic pathways Biosynthesis of amino acids
L-threonine KEGG C00188	Glycine, serine and threonine metabolism Valine, leucine and isoleucine biosynthesis Porphyrin and chlorophyll metabolism Aminoacyl-tRNA biosynthesis Metabolic pathways Biosynthesis of amino acids ABC transporters Protein digestion and absorption Mineral absorption
N-acetyl-beta-alanine KEGG C01073	beta-Alanine metabolism
N-acetylneuraminate KEGG C00270	Amino sugar and nucleotide sugar metabolism Metabolic pathways
N-acetylornithine KEGG C00437	Arginine biosynthesis Metabolic pathways 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids
N-methyl-4-pyridone-3-carboxamide KEGG C05843	Nicotinate and nicotinamide metabolism Metabolic pathways
N6-acetyl-L-lysine KEGG C02727	Lysine degradation
N6-acetyl-lysine	Metabolic pathways
NAD+ KEGG C00003	Oxidative phosphorylation Thiamine metabolism Nicotinate and nicotinamide metabolism Drug metabolism - other enzymes Metabolic pathways AMPK signaling pathway Longevity regulating pathway Aldosterone synthesis and secretion Vitamin digestion and absorption
NADP+ KEGG C00006	Glutathione metabolism Nicotinate and nicotinamide metabolism Drug metabolism - other enzymes Metabolic pathways Thyroid hormone synthesis Aldosterone synthesis and secretion
Norepinephrine KEGG C00547	Tyrosine metabolism Metabolic pathways cAMP signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Thermogenesis Regulation of lipolysis in adipocytes Renin secretion
UDP-acetyl-glucosamine KEGG C00043	Amino sugar and nucleotide sugar metabolism Neomycin, kanamycin and gentamicin biosynthesis Metabolic pathways Insulin resistance
Vanillylmandelic acid (VMA) KEGG C05584	Tyrosine metabolism Metabolic pathways
acetone KEGG C00207	Synthesis and degradation of ketone bodies Metabolic pathways Propanoate metabolsim
acetylphenylalanine KEGG C03519	Phenylalanine metabolism Metabolic pathways
alpha-tocopherol KEGG C02477	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Ferroptosis Vitamin digestion and absorption
androstenediol KEGG C04295	Steroid hormone biosynthesis Ovarian steroidogenesis
androstenedione KEGG C00280	Steroid hormone biosynthesis Ovarian steroidogenesis Metabolic Pathways Endocrine resistance Prolactin signaling pathway Pathways in cancer Prostate cancer
androsterone glucuronide KEGG C11135	Steroid hormone biosynthesis
arachidonic acid KEGG C00219	Arachidonic acid metabolism Linoleic acid metabolism Biosynthesis of unsaturated fatty acids Metabolic pathways Ferroptosis Necroptosis Vascular smooth muscle contraction Platelet activation Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Retrograde endocannabinoid signaling Serotonergic synapse Long-term depression Inflammatory mediator regulation of TRP channels GnRH signaling pathway Ovarian steroidogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Aldosterone synthesis and secretion Leishmaniasis Amoebiasis
arginine KEGG C00062	Arginine biosynthesis Arginine and proline metabolism D-Arginine and D-ornithine metabolism Aminoacyl-tRNA biosynthesis Metabolic pathways Biosynthesis of amino acids ABC transporters mTOR signaling pathway Protein digestion and absorption Amytrophic lateral sclerosis (ALS) Salmonella infection Chagas disease (American trypanosomiasis) Amoebiasis Central carbon metabolism in cancer
beta-hydroxyisovalerate KEGG C20827	Valine, leucine and isoleucine degradation Metabolic pathways
beta-tocopherol KEGG C14152	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways
betaine KEGG C00719	Glycine, serine and threonine metabolism Metabolic pathways ABC transporters
caffeine KEGG C07481	Caffeine metabolism Metabolic pathways
campesterol KEGG C01789	Steroid biosynthesis Metabolic pathways
carnitine KEGG C00487	Lysine degradation ABC transporters
carnosine KEGG C00386	Histidine metabolism beta-Analine metabolism Metabolic pathways
cholesterol KEGG C00187	Steroid biosynthesis Primary bile acid biosynthesis Steroid hormone biosynthesis Steroid degradation Metabolic pathways Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Fat digestion and absorption Bile secretion Vitamin digestion and absorption Cholesterol metabolism Pathways in cancer Basal cell carcinoma
choline KEGG C00114	Glycine, serine and threonine metabolism Glycerophospholipid metabolism Metabolic pathways ABC transporters Cholinergic synapse Bile secretion Choline metabolism in cancer
choline phosphate KEGG C00588	Glycerophospholipid metabolism Metabolic pathways Choline metabolism in cancer
citrate KEGG C00158	Citrate cycle (TCA cycle) Alanine, aspartate and glutamate metabolism Glyoxylate and dicarboxylate metabolism Biosynthesis of secondary metabolites Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Taste transduction Glucagon signaling pathway Central carbon metabolism in cancer
citric acid KEGG C00158	Citrate cycle (TCA cycle) Alanine, aspartate and glutamate metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Taste transduction Glucagon signaling pathway Central carbon metabolism in cancer
cortisone KEGG C00762	Steroid hormone biosynthesis Metabolic pathways Aldosterone-regulated sodium reabsorption Pathways in cancer Prostate cancer
creatine KEGG C00300	Glycine, serine and threonine metabolism Arginine and proline metabolism Metabolic pathways
creatinine KEGG C00791	Arginine and proline metabolism Metabolic pathways
dehydroepiandrosterone KEGG C01227	Steroid hormone biosynthesis Ovarian steroidogenesis Metabolic Pathways Pathways in cancer Prostate cancer Steroid degradation
dehydroepiandrosterone sulphate KEGG C04555	Steroid hormone biosynthesis Bile secretion
dimethyl sulfone KEGG C11142	Sulfur metabolism Metabolic pathways
dimethylamine KEGG C00543	Metabolic pathways Carbon metabolism
dimethylglycine KEGG C01026	Glycine, serine and threonine metabolism Metabolic pathways
erythriol KEGG C00503	ABC transporters
etiocholanolone glucuronide KEGG C11136	Steroid hormone biosynthesis
formate KEGG C00058	Pyruvate metabolism
fumaric acid KEGG C00122	Citrate cycle (TCA cycle) Oxidative phosphorylation Arginine biosynthesis Alanine, aspartate and glutamate metabolism Tyrosine metabolism Phenylalanine metabolism Pyruvate metabolism Butanoate metabolism Nicotinate and nicotinamide metabolism Metabolic pathways Carbon metabolism Glucagon signaling pathway Pathways in cancer Renal cell carcinoma Central carbon metabolism in cancer
gamma-tocopherol KEGG C02483	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways
glutarate KEGG C00489	Fatty acid degradation Lysine degradation Metabolic pathways
glutathione KEGG C00051	Cysteine and methionine metabolism Glutathione metabolism Metabolic pathways ABC transporters Ferroptosis Thyroid hormone synthesis Bile secretion
glycerophosphoethanolamine KEGG C01233	Glycerophospholipid metabolism Ether lipid metabolism
glycine KEGG C00037	Primary bile acid biosynthesis Purine metabolism Glycine, serine and threonine metabolism Lysine degradation Phosphonate and phosphinate metabolism Glutathione metabolism Glyoxylate and dicarboxylate metabolism Thiamine metabolism Porphyrin and chlorophyll metabolism Aminoacyl-tRNA biosynthesis Metabolic pathways Carbon metabolism Biosynthesis of amino acids ABC transporters Neuroactive ligand-receptor interaction Synaptic vesicle cycle Protein digestion and absorption Mineral absorption Central carbon metabolism in cancer
guanidinoacetate KEGG C00581	Glycine, serine and threonine metabolism Arginine and proline metabolism Metabolic pathways
guanidinoacetic acid KEGG C00581	Glycine, serine and threonine metabolism Arginine and proline metabolism Metabolic pathways
gulonic acid KEGG C00800	Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Metabolic pathways
homovanillate (HVA) KEGG C05582	Tyrosine metabolism Metabolic pathways Dopaminergic synapse
hypoxanthine KEGG C00262	Purine metabolism Metabolic pathways
indoleacetate KEGG C00954	Tryptophan metabolism Tryptophan metabolism
inosine KEGG C00294	Purine metabolism Metabolic pathways
inositol 1-phosphate KEGG C01177	Inositol phosphate metabolism Metabolic pathways ABC transporters Phosphatidylinositol signaling system
kynurenic acid KEGG C01717	Tryptophan metabolism Metabolic pathways
lathosterol KEGG C01189	Steroid biosynthesis Metaboli pathways
leukotriene E4 KEGG C05952	Arachidonic acid metabolism Metabolic pathways Neuroactive ligand-receptor interaction Fc epsilon RI signaling pathway
linoleic acid KEGG C01595	Linoleic acid metabolism Biosynthesis of unsaturated fatty acids Metabolic pathways
myo-inositol KEGG C00137	Galactose metabolism Ascorbate and aldarate metabolism Inositol phosphate metabolism Metabolic pathways ABC transporters Phosphatidylinositol signaling system
niacinamide KEGG C00153	Nicotinate and nicotinamide metabolism Metabolic pathways Vitamin digestion and absorption
nicotinic acid KEGG C00253	Nicotinate and nicotinamide metabolism Metabolic pathways Pertussis
normetanephrine	Tyrosine metabolism Metabolic pathways
oxalic acid KEGG C00209	Purine metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways
oxoproline KEGG C02237	D-Glutamine and D-glutamate metabolism
p-hydroxyphenylacetic acid KEGG C00642	Tyrosine metabolism Phenylalanine metabolism Metabolic pathways
paraxanthine KEGG C13747	Caffeine metabolism Metabolic pathways
phenylglyoxylic acid KEGG C02137	Metabolic pathways
pregnelone KEGG C01953	Steroid hormone biosynthesis Ovarian steroidogenesis Metabolic pathways Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome
pregnenolone sulfate KEGG C18044	Steroid hormone biosynthesis
propylene glycol KEGG C00583	Propanoate metabolism Metabolic pathways
pyridoxic acid KEGG C00847	VItamin B6 metabolism Metabolic pathways
pyruvate KEGG C00022	Glycolysis/Gluconeogenesis Citrate cycle (TCA cycle) Pentose phosphate pathway Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Alanine, aspartate and glutamate metabolism Glycine, serine and threonine metabolism Cysteine and methionine metabolism Valine, leucine and isoleucine biosynthesis Arginine and proline metabolism Tyrosine metabolism Phenylalanine metabolism Taurine and hypotaurine metabolism Phosphonate and phosphinate metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Butanoate metabolism Thiamine metabolism Nicotinate and nicotinamide metabolism Pantothenate and CoA biosynthesis Terpenoid backbone biosynthesis Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids HIF-1 signaling pathway AMPK signaling pathway Insulin secretion Glucagon signaling pathway
quinic acid KEGG C00296	Phenylalanine, tyrosine and tryptophan biosynthesis Metabolic pathways
ribitol KEGG C00474	Pentose and glucuronate interconversions Riboflavin metabolism Metabolic pathways
scyllo-inositol KEGG C06153	Inositol phosphate metabolism Metabolic pathways
sphingosine 1-phosphate KEGG C06124	Sphingolipid metabolism Metabolic pathways Calcium signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Apelin signaling pathway Fc gamma R-mediated phagocytosis Tuberculosis
taurine KEGG C00245	Primary bile acid biosynthesis Taurine and hypotaurine metabolism Sulfur metabolism Metabolic pathways ABC transporters Neuroactive ligand-receptor interaction
testosterone glucuronide KEGG C11134	Steroid hormone biosynthesis
theobromine KEGG C07480	Caffeine metabolism Metabolic pathways
trans-4-hydroxyproline KEGG C01157	Arginine and proline metabolism Metabolic pathways ABC transporters
trimethylamine N-oxide KEGG C01104	Metabolic pathways
tryptamine KEGG C00398	Tryptophan metabolism Metabolic pathways Neuroactive ligand-receptor interaction
urate KEGG C00366	Purine metabolism Metabolic pathways Bile secretion
urea KEGG C00086	Arginine biosynthesis Purine metabolism Pyrimidine metabolism Arginine and proline metabolism Biotin metabolism Metabolic pathways ABC transporters Epithelial cell signaling in Helicobacter pylori infection
uric acid KEGG C00366	Purine metabolism Metabolic pathways Bile secretion
uridine KEGG C00299	Pyrimidine metabolism Metabolic pathways
vanillylmandelate (VMA) KEGG C05584	Tyrosine metabolism Metabolic pathways
xanthine KEGG C00385	Purine metabolism Caffeine metabolism Metabolic pathways

Pathway	Metabolites
Caffeine metabolism	1,7-dimethyluric acid 1-methylxanthine caffeine paraxanthine theobromine xanthine
Metabolic pathways	1,7-dimethyluric acid 1-methylnicotinamide 1-methylxanthine 11,12-dihydroxy-eicosatrienoic acid 4-acetamidobutanoate 4-hydroxybenzoic acid 4-hydroxyphenylacetate 4-methyl-2-oxopentanoate 5-methylthioadenosine (MTA) D-glucose D-glucuronate D-mannitol D-mannose D-ribose D-sorbitol D-xylose Dihydroxymandelic acid (DHMA) L-citrulline L-threonine N-acetylneuraminate N-acetylornithine N-methyl-4-pyridone-3-carboxamide N6-acetyl-lysine NAD+ NADP+ Norepinephrine UDP-acetyl-glucosamine Vanillylmandelic acid (VMA) acetone acetylphenylalanine alpha-tocopherol arachidonic acid arginine beta-hydroxyisovalerate beta-tocopherol betaine caffeine campesterol carnosine cholesterol choline choline phosphate citric acid cortisone creatine creatinine dimethyl sulfone dimethylamine dimethylglycine fumaric acid gamma-tocopherol glutarate glutathione glycine guanidinoacetate guanidinoacetic acid gulonic acid homovanillate (HVA) hypoxanthine inosine inositol 1-phosphate kynurenic acid leukotriene E4 linoleic acid myo-inositol niacinamide nicotinic acid normetanephrine oxalic acid p-hydroxyphenylacetic acid paraxanthine phenylglyoxylic acid pregnelone propylene glycol pyridoxic acid pyruvate quinic acid ribitol scyllo-inositol sphingosine 1-phosphate taurine theobromine trans-4-hydroxyproline trimethylamine N-oxide tryptamine urate urea uric acid uridine vanillylmandelate (VMA) xanthine
Nicotinate and nicotinamide metabolism	1-methylnicotinamide S P N-methyl-4-pyridone-3-carboxamide NAD+ S P NADP+ S P fumaric acid S niacinamide S P nicotinic acid S P pyruvate S
Bile secretion	1-methylnicotinamide D-glucose L-carnitine cholesterol S P choline dehydroepiandrosterone sulphate glutathione uric acid
Arachidonic acid metabolism	11,12-dihydroxy-eicosatrienoic acid 8-iso prostaglandin F2α S P arachidonic acid S leukotriene E4 S P
Serotonergic synapse	11,12-dihydroxy-eicosatrienoic acid arachidonic acid
Arginine and proline metabolism	4-acetamidobutanoate S P creatine S P creatinine S P guanidinoacetate S P guanidinoacetic acid S P pyruvate trans-4-hydroxyproline S P urea
Ubiquinone and other terpenoid-quinone biosynthesis	4-hydroxybenzoic acid S P alpha-tocopherol P beta-tocopherol S P gamma-tocopherol S P
Folate biosynthesis	4-hydroxybenzoic acid
Tyrosine metabolism	4-hydroxyphenylacetate S P Norepinephrine Vanillylmandelic acid (VMA) S P fumaric acid homovanillate (HVA) P normetanephrine S P p-hydroxyphenylacetic acid S P pyruvate vanillylmandelate (VMA) S P
Phenylalanine metabolism	4-hydroxyphenylacetate acetylphenylalanine fumaric acid p-hydroxyphenylacetic acid pyruvate
Valine, leucine and isoleucine degradation	4-methyl-2-oxopentanoate S P beta-hydroxyisovalerate P
Valine, leucine and isoleucine biosynthesis	4-methyl-2-oxopentanoate L-threonine S pyruvate
2-Oxocarboxylic acid metabolism	4-methyl-2-oxopentanoate N-acetylornithine S P citrate S P citric acid S pyruvate
Biosynthesis of amino acids	4-methyl-2-oxopentanoate L-citrulline S P L-threonine N-acetylornithine arginine S P citrate citric acid glycine S P pyruvate
Cysteine and methionine metabolism	5-methylthioadenosine (MTA) S P glutathione pyruvate
Linoleic acid metablism	9-oxo-octadecadienoic acid P
Glycolysis/Gluconeogenesis	D-glucose pyruvate
Pentose phosphate pathway	D-glucose D-ribose S P pyruvate
Galactose metabolism	D-glucose D-mannose S P D-sorbitol S P myo-inositol S P
Starch and sucrose metabolism	D-glucose
Amino sugar and nucleotide sugar metabolism	D-glucose D-glucuronate S D-mannose D-xylose P N-acetylneuraminate S P UDP-acetyl-glucosamine S P
Neomycin, kanamycin and gentamicin biosynthesis	D-glucose UDP-acetyl-glucosamine
ABC transporters	D-glucose D-mannitol D-mannose D-ribose D-sorbitol D-xylose L-threonine arginine betaine carnitine choline erythriol glutathione glycine inositol 1-phosphate myo-inositol taurine trans-4-hydroxyproline urea
HIF-1 signaling pathway	D-glucose pyruvate
FoxO signaling pathway	D-glucose
AMPK signaling pathway	D-glucose NAD+ pyruvate
Taste transduction	D-glucose citrate citric acid
Insulin signaling pathway	D-glucose
Insulin secretion	D-glucose pyruvate
Prolactin signaling pathway	D-glucose androstenedione
Glucagon signaling pathway	D-glucose citrate citric acid fumaric acid pyruvate
Carbohydrate digestion and absorption	D-glucose
Mineral absorption	D-glucose L-threonine glycine
Pentose and glucuronate interconversions	D-glucuronate D-xylose pyruvate ribitol
Ascorbate and aldarate metabolism	D-glucuronate gulonic acid myo-inositol pyruvate
Inositol phosphate metabolism	D-glucuronate inositol 1-phosphate myo-inositol scyllo-inositol
Fructose and mannose metabolism	D-mannitol D-mannose D-sorbitol
Lysosome	D-mannose
C-type lectin receptor signaling pathway	D-mannose
Glycerophospholipid metabolism	L-alpha-glycerophosphoryl choline choline choline phosphate glycerophosphoethanolamine
Ether lipid metabolism	L-alpha-glycerophosphoryl choline glycerophosphoethanolamine P
Choline metabolism in cancer	L-alpha-glycerophosphoryl choline S P choline choline phosphate S P
Thermogenesis	L-carnitine
Arginine biosynthesis	L-citrulline N-acetylornithine arginine fumaric acid urea
Glycine, serine and threonine metabolism	L-threonine betaine S P choline creatine dimethylglycine S P glycine guanidinoacetate guanidinoacetic acid pyruvate
Porphyrin and chlorophyll metabolism	L-threonine glycine
Aminoacyl-tRNA biosynthesis	L-threonine arginine glycine
Protein digestion and absorption	L-threonine arginine glycine
beta-Alanine metabolism	N-acetyl-beta-alanine S
Lysine degradation	N6-acetyl-L-lysine S P carnitine P glutarate glycine
Oxidative phosphorylation	NAD+ fumaric acid
Thiamine metabolism	NAD+ glycine pyruvate
Drug metabolism - other enzymes	NAD+
Longevity regulating pathway	NAD+
Aldosterone synthesis and secretion	NAD+ NADP+ arachidonic acid cholesterol pregnelone
Vitamin digestion and absorption	NAD+ alpha-tocopherol cholesterol niacinamide
Glutathione metabolism	NADP+ glutathione glycine
Drug metabolism - other enzymes	NADP+
Thyroid hormone synthesis	NADP+ glutathione
cAMP signaling pathway	Norepinephrine
Neuroactive ligand-receptor interaction	Norepinephrine glycine leukotriene E4 sphingosine 1-phosphate taurine tryptamine
Vascular smooth muscle contraction	Norepinephrine arachidonic acid
Thermogenesis	Norepinephrine
Regulation of lipolysis in adipocytes	Norepinephrine arachidonic acid
Renin secretion	Norepinephrine
Insulin resistance	UDP-acetyl-glucosamine
Synthesis and degradation of ketone bodies	acetone
Propanoate metabolsim	acetone S P
Ferroptosis	alpha-tocopherol arachidonic acid glutathione
Steroid hormone biosynthesis	androstenediol S P androstenedione androsterone glucuronide P cholesterol cortisone dehydroepiandrosterone S P dehydroepiandrosterone sulphate etiocholanolone glucuronide pregnelone pregnenolone sulfate testosterone glucuronide
Ovarian steroidogenesis	androstenediol androstenedione arachidonic acid cholesterol dehydroepiandrosterone pregnelone
Metabolic Pathways	androstenedione dehydroepiandrosterone
Endocrine resistance	androstenedione
Pathways in cancer	androstenedione cholesterol cortisone dehydroepiandrosterone fumaric acid
Prostate cancer	androstenedione cortisone dehydroepiandrosterone
Linoleic acid metabolism	arachidonic acid linoleic acid
Biosynthesis of unsaturated fatty acids	arachidonic acid linoleic acid P
Necroptosis	arachidonic acid
Platelet activation	arachidonic acid
Fc epsilon RI signaling pathway	arachidonic acid leukotriene E4
Fc gamma R-mediated phagocytosis	arachidonic acid sphingosine 1-phosphate
Retrograde endocannabinoid signaling	arachidonic acid
Long-term depression	arachidonic acid
Inflammatory mediator regulation of TRP channels	arachidonic acid
GnRH signaling pathway	arachidonic acid
Oxytocin signaling pathway	arachidonic acid
Leishmaniasis	arachidonic acid
Amoebiasis	arachidonic acid arginine
Arginine and proline metabolism	arginine
D-Arginine and D-ornithine metabolism	arginine
mTOR signaling pathway	arginine
Amytrophic lateral sclerosis (ALS)	arginine
Salmonella infection	arginine
Chagas disease (American trypanosomiasis)	arginine
Central carbon metabolism in cancer	arginine citrate citric acid fumaric acid glycine
Steroid biosynthesis	campesterol cholesterol lathosterol
Histidine metabolism	carnosine
beta-Analine metabolism	carnosine
Primary bile acid biosynthesis	cholesterol glycine taurine
Steroid degradation	cholesterol dehydroepiandrosterone
Cortisol synthesis and secretion	cholesterol pregnelone
Cushing syndrome	cholesterol pregnelone
Fat digestion and absorption	cholesterol
Cholesterol metabolism	cholesterol
Basal cell carcinoma	cholesterol
Cholinergic synapse	choline
Citrate cycle (TCA cycle)	citrate citric acid fumaric acid pyruvate
Alanine, aspartate and glutamate metabolism	citrate citric acid fumaric acid pyruvate
Glyoxylate and dicarboxylate metabolism	citrate citric acid glycine oxalic acid pyruvate
Biosynthesis of secondary metabolites	citrate
Carbon metabolism	citrate citric acid dimethylamine S P fumaric acid glycine pyruvate
Aldosterone-regulated sodium reabsorption	cortisone
Sulfur metabolism	dimethyl sulfone taurine S P
Pyruvate metabolism	formate S P fumaric acid pyruvate
Butanoate metabolism	fumaric acid pyruvate
Renal cell carcinoma	fumaric acid
Fatty acid degradation	glutarate S
Purine metabolism	glycine hypoxanthine S P inosine S P oxalic acid P urate S P urea uric acid xanthine
Phosphonate and phosphinate metabolism	glycine pyruvate
Synaptic vesicle cycle	glycine
Pentose and glucuronate interconversions	gulonic acid S P
Dopaminergic synapse	homovanillate (HVA)
Tryptophan metabolism	indoleacetate S P kynurenic acid tryptamine S P
Tryptophan metabolism	indoleacetate S P
Phosphatidylinositol signaling system	inositol 1-phosphate S P myo-inositol
Metaboli pathways	lathosterol
Pertussis	nicotinic acid
D-Glutamine and D-glutamate metabolism	oxoproline P
Propanoate metabolism	propylene glycol S P
VItamin B6 metabolism	pyridoxic acid
Taurine and hypotaurine metabolism	pyruvate taurine
Pantothenate and CoA biosynthesis	pyruvate
Terpenoid backbone biosynthesis	pyruvate
Phenylalanine, tyrosine and tryptophan biosynthesis	quinic acid S P
Riboflavin metabolism	ribitol P
Sphingolipid metabolism	sphingosine 1-phosphate
Calcium signaling pathway	sphingosine 1-phosphate
Sphingolipid signaling pathway	sphingosine 1-phosphate
Phospholipase D signaling pathway	sphingosine 1-phosphate
Apelin signaling pathway	sphingosine 1-phosphate
Tuberculosis	sphingosine 1-phosphate
Bile secretion	urate
Pyrimidine metabolism	urea uridine S P
Biotin metabolism	urea
Epithelial cell signaling in Helicobacter pylori infection	urea S

The MetaboAge Database is a freely available electronic database with the main goal to host high-quality, manually curated, and detailed information about human small molecule metabolites that are involved in the aging signature. Briefly, the metabolites included in this database are small molecules that present variation in different age stages. Also, MetaboAge provides an encyclopedic reference on human metabolic pathways of these molecules. It is intended to be used for better knowledge and understanding of the aging process and has applications in metabolomics, clinical chemistry, biomarker discovery, and general education.